effects of immobilization on collagen
I think a web based computer search such as on PubMed.gov should give you more than you would ever want. One excellent book is Dynamics of Human Biological Tissues by Dean P. Currier and Roger M. Nelson.
Probably the most important take home message form all of this data is that we should be doing much longer durations for stretches and joint mobilization than is traditional and we are just beginning to see some real data in that arena.
I have for a few decades practised manual therapy by taking the joint to its end-range and maintaining the applied force for 2 to 5 minutes the caveat being for chronic, not acute conditions. Same for stretching though recent data shows that 10 minutes may be even more effective (unpublished data).
It seems to me to be a common sense interpretation of the literature on the topic. I hope we will see lots more work in this area and we may be significantly changing the way we teach stretchiing and joint mobilization on this basis.
Great topic-very relevant. Best of Luck.
Jerry Hesch, MHS, PT
Re: effects of immobilization on collagen
Effect of Immobilisation on Collagen
It would be worth looking at a couple of chapters on the soft-tissue healing process in any Cyriax books - Cyriax and Cyriax (1990ish) or Kesson and Atkins (2002ish) - as background reading and even to find some relevant references.
There are also a couple of interesting articles by Glenn Hunter on the topic of Specific Soft-Tissue Mobilisation (SSTM) techniques, which gives another good account of soft-tissue healing and the rationale for progressive laoding of healing soft-tissue.