Woking in the UK

Hi,
I am traveling to the UK in a few weeks. I have registered my self with HPC and have a relevant visa to work there indefinitely. I graduated in 2006 and since then have had a steady job and made good contacts with Doctors in their respected fields who are more than happy to give me good recommendation letters for never letting them down every time they referred a patient.
For the past couple of months i have used this good site (Physiobob), in finding work for myself in UK. I have found many in the weekly newsletter, but whenever i apply for any work i never get a reply. So i was wondering if you could please guide me and help me if I am doing anything wrong, or if anyone knows someone personally at a hospital in UK who could help me find a job.
Thanks all and hope to hear from you guys soon.