I have not read the latest research on creatine supplimentation. Basically what I found in the literature that I read was that EIMC, specifically those in the calf, where the muscle spans 2 joints are likely to cramp more due to lack of reciprocal inhibition & increased excitation of alpha motor neurones.

Generally that the problem of cramping in calf muscles was localised to the muscle, rather than systemic..electrolyte / dehydration problems etc...

Thus treating with STM, stretches, accupressure and re-eduction of muscle control was more likely to improve things.