First of all, I think we need to be sure that the knee problem and wrist problem are two seperate issues.Which I think they must be since you are laughing happily...anyways if you are not getting any freedom from any treatment, consider getting an injection dose.But I would really like you to reassure me that the knee and wrist are not the same thing, maybe you want to tell me about the knee etc. and possibly if anyone in ur family has had a similar case.