I think you'd probably look at suctioning lastly especially if he's got RR of 40 suggesting hes in some sort of resp failure.
Good if you know what his ABGS are. Firstly I would use positioning and mobilise the patient unless there were any other contraindications. Yes, he shouldn't be on NP on such a high flow of O2 (9Lit). If he needs those levels of o2 to maintain his sats then you may need to look at an aquapak-ie provides humidified 02.. Best to look at as much info as you can, identifty main problems and treat within any contraindications..