It has been a couple of years since the original posts, but I'm also looking for more information about shin pain at night. My 22-year-old son has a mitochondrial disease and suffers from various odd pains now and then which never seem to amount to any firm diagnosis other than "it's probably related to his disease." It's never much help to hear this since I don't know how to help him manage the pain or alleviate the problem. For the past week, he has been complaining about his shins hurting, but only in the late afternoon and evening. His leg gets stiff and he can barely walk by bedtime. He winces and cries with the pain. In the morning, he seems much better. I have been trying Acetaminophen, Advil, Aleve, and heating pads in case it's just a cramp. He seems to like the heating pad, but it doesn't seem to be alleviating anything. The Acetaminophen, Advil, and Aleve don't seem to work either. I am reluctant to spend more money on doctors because I never get answers. He is intellectually impaired and isn't much help in describing further details on the complaint. Any help or ideas would be appreciated. Thank you in advance!