Both Parkinson's and Dystonic events are produced by dysfunction within the same neural circuitry involving the basal ganglia.

What hand is affected?

Look at his pupils... Is one larger than the other one?

Basically, basal ganglionic functions are regulated by descending input from ipsilateral cortical centers. Therefore, at some level, these are inappropriately modulating output to the muscles of the hand during writing tasks for your uncle. These circuits exist on the brain C/L to the side of the lesion (in this case the hand). From a manual therapy approach, an attempt to increase afferentation to cortical centers through any sensory modality that will increase decending modulation to basal ganglionic circuits should be attempted. This does not necessarily mean electrotherapies or manipulation, although they may be used if parietal functions have been assessed and deemed the major deficient system.

Such effects can be seen in this video on youtube (I realize this is not a great "scientific" reference, however, for lack of other visual demonstration please humor me). YouTube - Dyskinesia and Blue Lenses What you are seeing is that a blue filter in lenses is changing the firing patters from the occipital cortex which is responding to differences in the frequency of light. Blue light is of a higher frequency than red light. Decreasing or (in this case) increasing firing from an occipital lobe will have an effect on modulating the overall activity in basal ganglionic and resultant thalmo-cortical circuitry which, as I'm sure you are aware, regulates output from primary motor centers. This is important, as this output is producing both the unwanted movement ie the choreioform movement in the video and focal dystonic event in your uncle's hand.

You can try these glasses which I have used successfully on some patients for similar dystonic events. You can try both the blue/red and dark/red combination's and simply test with a timed writing test improve his symptoms as he writes. NOTE *** rest periods inbetween ie. a day between trials is needed*** use a stopwatch to time*** Try each of the following:

1. Red/blue with Red to the right side.... Time a set writing task
2. Red/blue with Blue to the right side.... Time the same writing task
3 Red/dark with dark to the right side.... Time the same writing task
4. Red/dark with Red to the right side.... Time the same writing task.

If your uncle has a deficient visual sensory integration issue it will likely appear to improve with one of the above tests. Remember to do the same writing test to maintain consistency and NOTE which way the lenses were facing when his symptoms improved.

Pick's Reversible Frame Hemifield Stimulator Goggles

Pick's Reversible Frame Hemifield Stimulator Goggles

try both the above. tell me the hand. tell me if he has an anisochoria.

You can get back to me and I will discuss treatment options further if you are interested.

If you are really up to snuff on your neurology you will understand this article and be able to apply it to what I have said above:

Elsevier

Cheers,
SPPAWA